136949-31-0Relevant academic research and scientific papers
Synthesis and antitumor evaluation of novel cyclic arylsulfonylureas: ADME-T and pharmacophore prediction
El-Deeb, Ibrahim M.,Bayoumi, Said M.,El-Sherbeny, Magda A.,Abdel-Aziz, Alaa A.-M.
scheme or table, p. 2516 - 2530 (2010/07/05)
Novel derivatives of 5-(substituted)benzylidene-3-(4-substituted)phenylsulfonylimidazolidine-2,4-diones (3a-r), 1-(4-substituted)phenylsulfonyl-3-(4-substituted)phenylpyrimidine-2,4,6-(1H,3H,5H)-triones (6a-l), and 3-(4-substituted)phenyl-1-(4-substituted)phenylsulfonylquinazoline-2,4(1H,3H)- diones (8a-l) have been synthesized and tested for their antitumor activity against 60 tumor cell lines taken from 9 different organs. The tested compounds have showed good inhibitory effect at the ovarian cancer (IGROV1) cell line. A significant inhibition for (RXF393) renal cancer cells was observed with series 3 compounds, while in the other two series 6 and 8, there was a significant inhibition of ovarian cancer cells (OVCAR-8) and melanoma cells (SK-MEL-2). Interestingly; beside the strong inhibition of compound 3q to IGROV1 and RXF393 cells, a great inhibition (199.62%) for (M14) Melanoma cells was observed at the tested concentration (10?μM). ADME-T and pharmacophore prediction methodology were used to study the antitumor activity of the most active compounds and to identify the structural features required for antitumor activity.
Anticonvulsant Activity of Phenylmethylenehydantoins: A Structure-Activity Relationship Study
Thenmozhiyal, Jeyanthi Chinnappa,Wong, Peter Tsun-Hon,Chui, Wai-Keung
, p. 1527 - 1535 (2007/10/03)
Phenylmethylenehydantoins (PMHs) and their des-phenyl analogues were synthesized and evaluated for anticonvulsant activity using the maximal electroshock seizure (MES) assay. The phenyl rings of PMHs were substituted with a wide spectrum of groups, and th
TRIETHYLAMINE, ETHANOL- MEDIATED DISCIPLINED REACTIONS OF S-BENZYLISOTHIOURONIUM CHLORIDE WITH UNSATURATED 2-OXAZOLIN-5-ONES: SYNTHESIS OF (Z)-2-AMINO-4-ARYLMETHYLENE-2-IMIDAZOLIN-5-ONES, 5-BENZOYLAMINO-2-BENZYLTHIO-6-OXO-4,4-SPIROCYCLOHEXYL-1,4,5,6-TETRA
Mukerjee, Arya K.,Joseph, Kiran,Homami, Seyed-Saied,Tikdari, Ahmad M.
, p. 1317 - 1325 (2007/10/02)
Triethylamine-mediated condensation of S-benzylisothiouronium chloride with (Z)-4-arylmethylene-2-phenyl-2-oxazolin-5-ones (4) in ethanol gives (Z)-2-amino-4-arylmethylene-2-imidazolin-5-ones (7), whereas the similar reaction with 4-cyclohexylidene-2-phen
