1369530-77-7

Basic information

• Product Name: (S)-3-(4-bromo-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one
• Synonyms: (S)-3-(4-bromo-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one;Tedizolid Impurity 38;(5S)-3-(4-Bromo-3-fluorophenyl)-5-(hydroxymethyl)-2-oxazolidinone;Tedizolid Impurity 36
• CAS NO: 1369530-77-7
• Molecular Formula: C10H9BrFNO3
• Molecular Weight: 290.0857632
• Mol File: 1369530-77-7.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 401.6±35.0 °C(Predicted)
• Appearance: /
• Density: 1.701±0.06 g/cm3(Predicted)
• PKA: 14.05±0.10(Predicted)
• CAS DataBase Reference: (S)-3-(4-bromo-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(4-bromo-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one(1369530-77-7)
• EPA Substance Registry System: (S)-3-(4-bromo-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one(1369530-77-7)

Safety Data

• Hazardous Substances Data: 1369530-77-7(Hazardous Substances Data)

Usage

General Description

"(S)-3-(4-bromo-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one" is a chemical compound with potential pharmaceutical applications. It belongs to the oxazolidinone class of compounds, which have shown promising antibacterial properties. This particular compound contains a bromo-fluoro substituted phenyl group and a hydroxymethyl oxazolidinone moiety, which may contribute to its bioactivity and pharmacokinetic properties. Further research and development of this compound may lead to the discovery of novel antibiotics or other therapeutic agents for the treatment of infectious diseases.

Upstream product

• 60827-45-4 (S)-3-chloropropan-1,2-diol 
• 288570-67-2 2-methylpropyl (4-bromo-3-fluorophenyl)carbamate 
• 372-19-0 meta-fluoroaniline 
• 149524-47-0 N-(carbobenzyloxy)-3-fluoroaniline 
• 510729-01-8 (4-bromo-3-fluorophenyl)carbamic acid benzyl ester 
• 60456-26-0 (R)-glycidyl butyrate 
• 656-65-5 3-fluoro-4-bromophenylamine 
• 149524-42-5 (5R)-3-(3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one 
• 136434-77-0 4-bromo-3-fluoroiodobenzene 
• 7517-99-9 5-hydroxymethyl-2-oxazolidinone 

Downstream Products

• 504438-22-6 (R)‐3‐(3‐fluoro‐4‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)phenyl)‐5‐(hydroxymethyl)‐oxazolidin‐2‐one 

Relevant articles and documents

Room Temperature Cu-Catalyzed N-Arylation of Oxazolidinones and Amides with (Hetero)Aryl Iodides

N,N′-Bis(pyridin-2-ylmethyl)oxalamide (BPMO) was found to be an apposite promoter for the Cu-catalyzed N-arylation of oxazolidinones and primary and secondary amides with (hetero)aryl iodides at room temperature. Excellent chemoselectivity reached between

OXAZOLIDINONE COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS

The present invention relates to oxazolidinone compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, E, and R1 are as defined herein. The present invention also relates to compositions which comprise at least one oxazolidinone compound of the invention. The invention also provides methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosiscomprising administering a therapeutically effective amount of an oxazolidinone of the invention and/or apharmaceutically acceptable salt thereof, or a composition comprising such compound and/or salt.

Oxazolidinone-quinolone hybrid antibiotics

The present invention relates to compounds of the Formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant bacteria: