1369558-71-3

Upstream product

• 766-96-1 4-bromo-1-ethynylbenzene 
• 292638-85-8 acrylic acid methyl ester 
• 16116-78-2 (4-bromophenyl)(trimethylsilyl)acetylene 

Downstream Products

• 1435518-23-2 7-(4-bromophenyl)-3-phenyl-1-(trimethylsilyl)hepta-1,6-diyn-3-ol 
• 1435518-48-1 7-(4-bromophenyl)-3-phenylhepta-1,6-diyn-3-yl benzoate 
• 1435517-82-0 6-bromo-3-phenyl-2,4a-dihydro-1H-fluoren-4-yl benzoate 
• 1148036-49-0 5-(4-bromophenyl)-1-phenylpent-4-yn-1-one 

Relevant academic research and scientific papers

Gold-catalyzed cycloisomerization of 1,6-diyne carbonates and esters to 2,4a-dihydro-1 H-fluorenes

A synthetic method to prepare 2,4a-dihydro-1H-fluorenes efficiently from gold(I)-catalyzed 1,2-acyloxy migration/cyclopropenation/Nazarov cyclization of 1,6-diyne carbonates and esters is described. The suggested reaction pathway provides rare examples of [2,3]-sigmatropic rearrangement in this class of compounds as well as the involvement of an in situ formed cyclopropene intermediate in gold catalysis. Experimental and ONIOM(QM:QM′) [our own n-layered integrated molecular orbital and molecular mechanics(quantum mechanics:quantum mechanics′)] computational studies based on the proposed Au carbenoid species provide insight into this unique selectivity.

Indium(III) chloride catalyzed conjugate addition reaction of alkynylsilanes to acrylate esters

A novel and efficient procedure for the synthesis of δ,γ- alkynyl esters by the conjugate addition of alkynylsilanes to acrylate esters in the presence of a catalytic amount of indium(III) chloride has been developed. This method provides a rapid and efficient access to substituted δ,γ-alkynyl esters.