1369558-91-7Relevant academic research and scientific papers
Venting-while-heating microwave-assisted synthesis of 3-arylthioindoles
La Regina, Giuseppe,Gatti, Valerio,Famiglini, Valeria,Piscitelli, Francesco,Silvestri, Romano
, p. 258 - 262 (2012)
We report the first example of venting-while-heating microwave-assisted synthesis of a small library of 3-arylthioindoles. Compounds were prepared in excellent isolated yields (90-98%) within 4 min in a closed vessel by treating indoles with disulfides in the presence of sodium hydride in anhydrous N,N-dimethylformamide. The method was not affected by electron-donating and -withdrawing substituents both on 3-arylthio moiety and at 2- and 5-positions of the indole nucleus.
