1369589-91-2Relevant academic research and scientific papers
Synthesis and biological activity of heterocycles from chalcone
Al-Ghulikah
experimental part, p. 1631 - 1637 (2012/09/07)
The reaction between aromatic or heteroaromatic ortho-diamines and chalcone 1a,b is a convenient and versatile method for the preparation of condensed 1,4-diazepines 2a,b and 4a,b. 2,4-Diaryl-2,3-dihydro[1,5]benzothiazepines 5a,b were obtained from the condensation of chalcone 1a,b with 2-aminothiophenol in presence of catalytic amount of acid. The reaction of 2,3-diaminopyridine with chalcone dibromides 6a,b afforded the corresponding enaminoketones 7a,b, which cyclized to 6,8-diaryl-7,8-dihydro-9H-pyrido[4,5-b][1,4]diazepine 9a,b under acid condition. All synthesized compounds were characterized using IR, 1H NMR, 13C NMR, MS and elemental analysis. The compounds were screened for their antibacterial and antifungal activities. The synthesized compounds have shown activity against all the bacterial and fungal strains.
