1369591-76-3Relevant articles and documents
Four-component synthesis of 2-(N,N-dialkylamino)-2,4,6-cycloheptatrien-1- one derivatives from tropolone, an isocyanide, a primary amine and an aldehyde via ugi-smiles coupling reaction
Massoudi, Abdolhossain,Amini, Issa,Ramazani, Ali,Nasrabadi, Fatemeh Zeinali,Ahmadi, Yavar
experimental part, p. 39 - 42 (2012/03/09)
The use of Smiles rearrangement in Ugi-type couplings with tropolone allows very straightforward multicomponent formation of 2-(N,N-dialkylamino)-2,4,6- cycloheptatrien-1-one derivatives. The Ugi four-component reaction of isocyanides with tropolone (2-hydroxy-2,4,6-cycloheptatrien-1-one), primary amines and aldehydes proceeds smoothly and cleanly under mild conditions to afford 2-(N,N-dialkylamino)-2,4,6-cycloheptatrien- 1-one derivatives in fairly good yields.
