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CAS

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1369596-05-3

C21H13BrClNO is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1369596-05-3 Structure

  • Basic information

    1. Product Name: C21H13BrClNO
    2. Synonyms:
    3. CAS NO:1369596-05-3
    4. Molecular Formula:
    5. Molecular Weight: 410.697
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1369596-05-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: C21H13BrClNO(CAS DataBase Reference)
    10. NIST Chemistry Reference: C21H13BrClNO(1369596-05-3)
    11. EPA Substance Registry System: C21H13BrClNO(1369596-05-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1369596-05-3(Hazardous Substances Data)

1369596-05-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1369596-05-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,9,5,9 and 6 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1369596-05:
(9*1)+(8*3)+(7*6)+(6*9)+(5*5)+(4*9)+(3*6)+(2*0)+(1*5)=213
213 % 10 = 3
So 1369596-05-3 is a valid CAS Registry Number.

1369596-05-3Relevant articles and documents

Substituted tetracyclic indole core derivatives of HCV NS5A inhibitor MK-8742

Yu, Wensheng,Zhou, Guowei,Coburn, Craig A.,Zeng, Qingbei,Tong, Ling,Dwyer, Michael P.,Hu, Bin,Zhong, Bin,Hao, Jinglai,Ji, Tao,Zan, Shuai,Chen, Lei,Mazzola, Robert,Kim, Jae-Hun,Sha, Deyou,Selyutin, Oleg,Rosenblum, Stuart B.,Lavey, Brian,Nair, Anilkumar G.,Heon Kim, Seong,Keertikar, Kerry M.,Rokosz, Laura,Agrawal, Sony,Liu, Rong,Xia, Ellen,Zhai, Ying,Curry, Stephanie,McMonagle, Patricia,Ingravallo, Paul,Asante-Appiah, Ernest,Chen, Shiying,Kozlowski, Joseph A.

, p. 4851 - 4856 (2016)

As part of an ongoing effort in NS5A inhibition at Merck we now describe our efforts for introducing substitution around the tetracyclic indole core of MK-8742. Fluoro substitution on the core combined with the fluoro substitutions on the proline ring improved the potency against GT1a Y93H significantly. However, no improvement on GT2b potency was achieved. Limiting the fluoro substitution to C-1 of the tetracyclic indole core had a positive impact on the potency against the resistance associated variants, such as GT1a Y93H and GT2b, and the PK profile as well. Compounds, such as 62, with reduced potency shifts between wild type GT1a to GT2b, GT1a Y93H, and GT1a L31V were identified.

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