136975-50-3Relevant academic research and scientific papers
Synthesis and pharmacological evaluation of pyrroloazepine derivatives as potent antihypertensive agents with antiplatelet aggregation activity
Mizuno, Akira,Inomata, Norio,Miya, Mikiko,Kamei, Tomoe,Shibata, Makoto,Tatsuoka, Toshio,Yoshida, Maki,Takiguchi, Chikako,Miyazaki, Tomoko
, p. 246 - 256 (2007/10/03)
A series of 1-aminoalkyl-pyrrolo[2,3-c]azepin-8-one derivatives was synthesized and evaluated as α1 adrenergic and serotonin 2 (5-HT2) receptor antagonists, with the aim of finding a novel antihypertensive agent potently exhibiting b
Pyrroloazepine derivatives
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, (2008/06/13)
Disclosed herein are pyrroloazepine derivatives, which are useful as therapeutics for circulatory diseases, represented by the following formula (I): STR1 wherein R means a hydrogen atom, a linear or branched C1-6 alkyl group or a C7-10 aralkyl group, A denotes a linear or branched C2-10 alkylene, alkenylene or alkynylene group, Z stands for O, NOR1 or NOCOR5 in which R1 and R5 is a hydrogen atom or an alkyl, aryl or aralkyl group, and Y means a particular piperidinyl or pyrrolidinyl group; and salts thereof. Their preparation processes are also disclosed.
