1369773-39-6

Basic information

• Product Name: AHU-377 (heMicalciuM salt)
• Synonyms: AHU-377 (heMicalciuM salt);(alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1);(2S,4R)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester,calcium salt(2:1);AHU-377 hemicalcium salt (2:1);Calciumbis(4-{[(1S,3R)-1-([1,1'-biphenyl]-4-ylmethyl)-4-ethoxy-3-methyl-4-oxobutyl] amino} -4-oxobutanoate);Sacubitril Hemicalcium salt;(αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt;Sacubitril Calcium
• CAS NO: 1369773-39-6
• Molecular Formula: C48H56CaN2O10
• Molecular Weight: 861.04364
• Product Categories: lcz696;LCZ 696;Pharmaceutical Intermediates;Intermediates
• Mol File: 1369773-39-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.24g/cm3 at 20℃
• Vapor Pressure: 0.001Pa at 20℃
• Storage Temp.: -20°C
• Solubility: DMSO (Slightly, Heated), Methanol (Slightly)
• CAS DataBase Reference: AHU-377 (heMicalciuM salt)(CAS DataBase Reference)
• NIST Chemistry Reference: AHU-377 (heMicalciuM salt)(1369773-39-6)
• EPA Substance Registry System: AHU-377 (heMicalciuM salt)(1369773-39-6)

Safety Data

• RIDADR: UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all
• Hazardous Substances Data: 1369773-39-6(Hazardous Substances Data)

Usage

Description

AHU-377 (heMicalciuM salt) is a chemical compound with specific properties that make it suitable for various applications across different industries. Its unique characteristics allow it to be utilized in a range of contexts, from pharmaceuticals to industrial processes.

Uses

Used in Pharmaceutical Industry:
AHU-377 (heMicalciuM salt) is used as an active pharmaceutical ingredient for its potential therapeutic effects. It may be employed in the development of new drugs or the enhancement of existing ones, contributing to improved patient outcomes.
Used in Chemical Industry:
In the chemical industry, AHU-377 (heMicalciuM salt) is used as a key component in the synthesis of various compounds. Its unique properties enable it to act as a catalyst or intermediate in chemical reactions, facilitating the production of desired products.
Used in Research and Development:
AHU-377 (heMicalciuM salt) is utilized as a research tool in the field of material science and biology. Its properties make it a valuable compound for studying the mechanisms of various biological processes and for developing new materials with specific characteristics.
Used in Drug Delivery Systems:
Similar to gallotannin, AHU-377 (heMicalciuM salt) can be employed in drug delivery systems to improve the bioavailability and therapeutic outcomes of certain medications. Its incorporation into novel drug delivery platforms may enhance the efficacy of drugs and reduce side effects.

Biochem/physiol Actions

Sacubitril (AHU377) is a prodrug inhibitor of the membrane metallo-endopeptidase neprilysin. Sacubitril forms half of the heart failure combination drug LCZ696, along with the angiotensin-receptor blocker Valsartan. Sacubitril (AHU377) is cojnverted by esterases into the active inhibitor LBQ657, which prevents neprilysin′s degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides. The AHU377 valsartan combination drug LCZ696 showed a reduction in the risk of cardiovascular death of 20% compared to the standard ACE inhibitor enalapril, and also a 21% drop in the risk of hospitalization.