1369800-50-9

Upstream product

• 5061-21-2 α-bromo-γ-butyrolactone 
• 1849-36-1 para-nitrobenzenethiol 

Downstream Products

• 1095660-34-6 3-[(4-aminophenyl)sulfanyl]dihydrofuran-2(3H)-one 
• 1369957-47-0 4-chloro-N-{4-[(2-oxotetrahydrofuran-3-yl)sulfanyl]phenyl}benzamide 
• 1369957-48-1 methyl 2-[(4-{[(4-chlorophenyl)carbonyl]amino}phenyl)sulfanyl]-4-hydroxybutanoate 
• 1369957-86-7 2-[(4-{[(4-chlorophenyl)carbonyl]amino}phenyl)sulfonyl]-4-{[(4-fluorophenyl)carbamoyl]oxy}butanoic acid 
• 1369957-45-8 2-[(4-{[(4-chlorophenyl)carbonyl]amino}phenyl)sulfanyl]-4-{[(4-fluorophenyl)carbamoyl]oxy}butanoic acid 
• 1369804-24-9 methyl 4-hydroxy-2-[(4-nitrophenyl)sulfanyl]butanoate 
• 1369804-17-0 4-methyl-N-{4-[(2-oxotetrahydrofuran-3-yl)sulfanyl]phenyl}benzamide 
• 1369804-19-2 methyl 4-hydroxy-2-[(4-{[(4-methylphenyl)carbonyl]amino}phenyl)sulfanyl]butanoate 
• 1369804-21-6 methyl 4-(6-methoxy-4-oxo-1,2,3-benzotriazin-3(4H)-yl)-2-[(4-{[(4-methylphenyl)carbonyl]amino}phenyl)sulfanyl]butanoate 
• 1369804-15-8 4-(6-methoxy-4-oxo-1,2,3-benzotriazin-3(4H)-yl)-2-[(4-{[(4-methylphenyl)carbonyl]amino}phenyl)sulfanyl]butanoic acid 
• 1369804-25-0 methyl 4-(6-methyl-4-oxo-1,2,3-benzotriazin-3(4H)-yl)-2-[(4-nitrophenyl)sulfanyl]butanoate 
• 1369804-29-4 methyl 2-[(4-aminophenyl)sulfanyl]-4-(6-methyl-4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoate 
• 1369804-30-7 methyl 4-(6-methyl-4-oxo-1,2,3-benzotriazin-3(4H)-yl)-2-[(4-{[(4-methylphenyl)carbonyl]amino}phenyl)sulfanyl]butanoate 
• 1369804-23-8 4-(6-methyl-4-oxo-1,2,3-benzotriazin-3(4H)-yl)-2-[(4-{[(4-methylphenyl)carbonyl]amino}phenyl)sulfanyl]butanoic acid 

Relevant academic research and scientific papers

Facile synthetic approaches to 1-thiocyclopropanecarboxylates

Two facile synthetic approaches to the novel biologically interesting 1-thiocyclopropanecarboxylates starting from corresponding thiols were developed. Approach A involved five steps with the key steps being the SN2 reactions of thiols and α-br

MATRIX METALLOPROTEINASE INHIBITORS

This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, periodontitis, multiple sclerosis, gingivitis, gingivitis, atherosclerosis, dry eye, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and pounds.

MATRIX METALLOPROTEINASE INHIBITORS

The present invention relates to certain sulfone acetic acid derivatives of formula I as MMP inhibitor and processes for its syntheses. The invention also relates to pharmacological compositions containing the compounds of the present invention and method

MATRIX METALLOPROTEINASE INHIBITORS

This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, dry eye, neointimal proliferation, which leads to restenosis and ischemic heart faliure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by over-expression and over-activation of matrix metalloproteinase using the compounds.