1369903-53-6Relevant academic research and scientific papers
Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides
Cho, Aesop,Saunders, Oliver L.,Butler, Thomas,Zhang, Lijun,Xu, Jie,Vela, Jennifer E.,Feng, Joy Y.,Ray, Adrian S.,Kim, Choung U.
, p. 2705 - 2707 (2012)
A series of 1′-substituted analogs of 4-aza-7,9-dideazaadenosine C-nucleoside were prepared and evaluated for the potential as antiviral agents. These compounds showed a broad range of inhibitory activity against various RNA viruses. In particular, the whole cell potency against HCV when R = CN was attributed to inhibition of HCV NS5B polymerase and intracellular concentration of the corresponding nucleoside triphosphate.
