1369906-10-4

Upstream product

• 6669-13-2 t-butyl phenyl ether 
• 1243414-06-3 2-bromo-6-tert-butoxyphenol 
• 36805-97-7 N,N-dimethylformamide di-tert-butyl acetal 
• 120-80-9 benzene-1,2-diol 
• 14381-51-2 3-bromo-1,2-dihydroxybenzene 
• 115-11-7 isobutene 
• 23010-10-8 t-butyl pyrocatechol 

Relevant academic research and scientific papers

Synthesis and use of ortho-(branched alkoxy)-tert-butoxybenzenes

A series of sterically hindered o-(branched alkoxy)-tert-butoxybenzenes was efficiently prepared in good yields owing to a new practical and simple preparation of o-tert-butoxyphenol starting from catechol and isobutene. Use of DMF di-tert-butyl acetal reagent instead of isobutene/H2SO 4 (cat.) for O-tert-butylation was very convenient in case of ortho bulky phenols affording the corresponding tert-butyl ethers in high yield and purity. This general route proved to be useful since no reliable access was available to o-di-t-BuO-substituted arenes. Application to the synthesis of congested phosphorus-based compounds is presented.