1369937-63-2Relevant academic research and scientific papers
Synthesis and use of ortho-(branched alkoxy)-tert-butoxybenzenes
Rast, Slavko,Stephan, Michel,Mohar, Barbara
supporting information, p. 6815 - 6818 (2013/01/15)
A series of sterically hindered o-(branched alkoxy)-tert-butoxybenzenes was efficiently prepared in good yields owing to a new practical and simple preparation of o-tert-butoxyphenol starting from catechol and isobutene. Use of DMF di-tert-butyl acetal reagent instead of isobutene/H2SO 4 (cat.) for O-tert-butylation was very convenient in case of ortho bulky phenols affording the corresponding tert-butyl ethers in high yield and purity. This general route proved to be useful since no reliable access was available to o-di-t-BuO-substituted arenes. Application to the synthesis of congested phosphorus-based compounds is presented.
