1369959-12-5 Usage
Description
5-Chloro-3-nitro-1H-pyrazole is a chemical compound characterized by the molecular formula C3H2ClN3O2. It is a yellow crystalline solid that features a pyrazole ring with a chlorine atom at the 5th position and a nitro group at the 3rd position. 5-chloro-3-nitro-1H-pyrazole is recognized for its role as a key intermediate in the synthesis of pharmaceuticals and agrochemicals, and it is valued for its unique chemical structure and reactivity, which contribute to the development of a variety of bioactive compounds.
Uses
Used in Pharmaceutical Industry:
5-Chloro-3-nitro-1H-pyrazole is used as a synthetic intermediate for the production of various pharmaceuticals. Its unique structure allows it to be a building block in the creation of new drugs, potentially contributing to advancements in medicinal chemistry and the treatment of various diseases.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Chloro-3-nitro-1H-pyrazole serves as an intermediate in the synthesis of crop protection products. Its reactivity and chemical properties make it suitable for the development of effective agents that can protect crops from pests and diseases, thereby enhancing agricultural productivity and crop yields.
The specific applications and properties of 5-chloro-3-nitro-1H-pyrazole may vary based on the synthesis method and the particular use for which it is intended, highlighting the compound's versatility in both the pharmaceutical and agrochemical fields.
Check Digit Verification of cas no
The CAS Registry Mumber 1369959-12-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,9,9,5 and 9 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1369959-12:
(9*1)+(8*3)+(7*6)+(6*9)+(5*9)+(4*5)+(3*9)+(2*1)+(1*2)=225
225 % 10 = 5
So 1369959-12-5 is a valid CAS Registry Number.
1369959-12-5Relevant articles and documents
PYRAZOLOPYRIMIDINE AS MALT-1 INHIBITORS
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Page/Page column 86, (2019/01/06)
The invention provides a compound of formula (I): herein R1, R2 and R3 of series (x), (y) and (z) are as defined in the specification which are potent inhibitors of the enzyme MALT1 and are useful in an immunooncology approach to the treatment of cancer, especially bladder cancer, colon cancer, hepatocellular cancer or small cell or non-small cell lung cancer.
Discovery of ((S)-5-(methoxymethyl)-7-(1-methyl-1 H -indol-2-yl)-2- (trifluoromethyl)-4,7-dihydropyrazolo[1,5- a ]pyrimidin-6-yl)((S)-2-(3- methylisoxazol-5-yl)pyrrolidin-1-yl)methanone as a potent and selective I Kur inhibitor
Finlay, Heather J.,Lloyd, John,Vaccaro, Wayne,Kover, Alexander,Yan, Lin,Bhave, Gauri,Prol, Joseph,Huynh, Tram,Bhandaru, Rao,Caringal, Yolanda,Dimarco, John,Gan, Jinping,Harper, Tim,Huang, Christine,Conder, Mary Lee,Sun, Huabin,Levesque, Paul,Blanar, Michael,Atwal, Karnail,Wexler, Ruth
experimental part, p. 3036 - 3048 (2012/06/01)
Previously disclosed dihydropyrazolopyrimidines are potent and selective blockers of IKur current. A potential liability with this chemotype is the formation of a reactive metabolite which demonstrated covalent binding to protein in vitro. When substituted at the 2 or 3 position, this template yielded potent IKur inhibitors, with selectivity over hERG which did not form reactive metabolites. Subsequent optimization for potency and PK properties lead to the discovery of ((S)-5-(methoxymethyl)-7-(1-methyl-1H-indol- 2-yl)-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)((S) -2-(3-methylisoxazol-5-yl)pyrrolidin-1-yl)methanone (13j), with an acceptable PK profile in preclinical species and potent efficacy in the preclinical rabbit atrial effective refractory period (AERP) model.
