1369963-65-4

Upstream product

• 5535-48-8 PVS 
• 213598-45-9 3,4-isopropylidenedioxy-Δ¹-pyrroline-1-oxide 
• 1369963-66-5 (3S,3aR,4S,5R)-3-phenylsulfonyl-4,5-isopropylidenedioxy-hexahydropyrrolo[1,2-b]isoxazole 

Downstream Products

• 1446141-89-4 (1′R,3S,4R)-3,4-isopropylidenedioxy-5-[(1′-phenylsulfonyl)(2′-phenyl)ethyl]-3,4-dihydro-2H-pyrrole 1-oxide 
• 1446141-81-6 (1′R,2R,3S,4R)-2-[(1′-phenylsulfonyl)propyl]-1-hydroxy-3,4-isopropylidenedioxypyrrolidine 
• 1446141-87-2 (1′R,2R,3S,4R)-2-[(1′-phenylsulfonyl)(3′-(4-methoxyphenyl))-propyl]-1-hydroxy-3,4-isopropylidenedioxypyrrolidine 
• 1446141-86-1 (1′R,2R,3S,4R)-2-[(1′-phenylsulfonyl)(3′-phenyl)propyl]-1-hydroxy-3,4-isopropylidenedioxypyrrolidine 
• 1446141-85-0 (1′R,2R,3S,4R)-2-[(1′-phenylsulfonyl)(2′-(4-fluorophenyl))ethyl]-1-hydroxy-3,4-isopropylidenedioxypyrrolidine 
• 1446141-84-9 (1′R,2R,3S,4R)-2-[(1′-phenylsulfonyl)(2′-phenyl)ethyl]-1-hydroxy-3,4-isopropylidenedioxypyrrolidine 
• 1446141-83-8 (1′R,2R,3S,4R)-2-[(1′-phenylsulfonyl)(4′-methyl)pent-4′-enyl]-1-hydroxy-3,4-isopropylidenedioxypyrrolidine 
• 1446141-82-7 (1′R,2R,3S,4R)-2-[(1′-phenylsulfonyl)(3′-methyl)pentyl]-1-hydroxy-3,4-isopropylidenedioxypyrrolidine 
• 1446141-80-5 (1′R,2R,3S,4R)-2-[(1′-phenylsulfonyl)hexyl]-1-hydroxy-3,4-isopropylidenedioxypyrrolidine 

Relevant academic research and scientific papers

Domino elimination/nucleophilic addition in the synthesis of chiral pyrrolidines

Polyhydroxylated pyrrolidines have been synthesized in a one-pot procedure by the addition of an organometallic reagent to isoxazolidines obtained by a 1,3-dipolar cycloaddition between nitrones and vinylsulfones. This method highlights sulfone reactivity and provides an easy approach for the preparation of chiral pyrrolidines using cyclic imines as key intermediates.

1,3-Dipolar cycloaddition of nitrones with phenylvinyl sulfone. An experimental and theoretical study

The addition of three nitrones to phenylvinylsulfone, 1, has been studied. The stereochemistry previously established by two-dimensional NMR techniques was confirmed by X-ray crystal structure determination. Theoretical studies made us propose that this r