1369965-69-4

Upstream product

• 34713-70-7 2-Phenylpropanal 
• 57842-27-0 1,3-benzodithiol-2-ylium tetrafluoroborate 

Downstream Products

• 1369965-82-1 2-((R)-1-(benzyloxy)-2-phenylpropan-2-yl)-2-methylbenzo-1,3-dithiole 
• 6006-75-3 (-)-2-methyl-2-phenyl-1-butanol 
• 28968-34-5 (R)-3-hydroxy-2-methyl-2-phenylpropanoic acid 
• 1369965-81-0 2-((R)-1-(benzyloxy)-2-phenylpropan-2-yl)benzo-1,3-dithiole 

Relevant academic research and scientific papers

A Versatile Organocatalytic Approach for the Synthesis of Enantioenriched gem-Difluorinated Compounds

The combination of a practical and highly enantioselective organocatalytic reaction, which allows the stereoselective introduction of a benzodithiol group, with a fluorination step, gives a new and effective strategy for the stereoselective synthesis of difluorinated building blocks. The benzodithiol group is a versatile and chameleonic group that can be further functionalized before fluorination, giving customized and tailored useful synthetic strategies. As an example of the application of this facile strategy, the effective enantioselective synthesis of difluoroarundic acid is described. All you need is fluor! The combination of a practical and highly enantioselective organocatalytic reaction with a fluorination step provides a new and effective strategy for the stereoselective synthesis of enantioenriched difluorinated building blocks (see scheme).

A general stereoselective enamine mediated alkylation of α-substituted aldehydes

We herein present a general enamine-mediated α-alkylation of α-substituted aldehydes with carbenium ions for the stereoselective construction of quaternary stereogenic centers.