13700-15-7 Usage
Uses
Used in Biological Research:
CARBOXYMETHYL METHANETHIOSULFONATE is used as a probe for studying the structures of various receptor channels and transport proteins, such as the ACh receptor channel, the GABA receptor channel, and lactose permease. Its ability to form mixed disulfides with thiols allows researchers to investigate the structural and functional aspects of these biological entities.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, CARBOXYMETHYL METHANETHIOSULFONATE is used as a reagent for the modification of thiol-containing compounds, which can be crucial in the development of new drugs and therapeutic agents. Its specificity and reactivity with thiols make it a valuable tool in the synthesis and optimization of drug candidates.
Used in Analytical Chemistry:
CARBOXYMETHYL METHANETHIOSULFONATE is also used in analytical chemistry as a derivatizing agent for the detection and quantification of thiols in various samples. Its ability to form stable mixed disulfides with thiols enables the development of sensitive and selective analytical methods for thiol analysis.
Check Digit Verification of cas no
The CAS Registry Mumber 13700-15-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,7,0 and 0 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 13700-15:
(7*1)+(6*3)+(5*7)+(4*0)+(3*0)+(2*1)+(1*5)=67
67 % 10 = 7
So 13700-15-7 is a valid CAS Registry Number.
InChI:InChI=1/C3H6O4S2/c1-9(6,7)8-2-3(4)5/h2H2,1H3,(H,4,5)
13700-15-7Relevant academic research and scientific papers
Gabriele, Elena,Ricci, Chiara,Meneghetti, Fiorella,Ferri, Nicola,Asai, Akira,Sparatore, Anna
, p. 337 - 344 (2017)
With the aim to discover new STAT3 direct inhibitors, potentially useful as anticancer agents, a set of methanethiosulfonate drug hybrids were synthesized. The in vitro tests showed that all the thiosulfonic compounds were able to strongly and selectively bind STAT3-SH2 domain, whereas the parent drugs were completely devoid of this ability. In addition, some of them showed a moderate antiproliferative activity on HCT-116 cancer cell line. These results suggest that methanethiosulfonate moiety can be considered a useful scaffold in the preparation of new direct STAT3 inhibitors. Interestingly, an unusual kind of organo-sulfur derivative, endowed with valuable antiproliferative activity, was occasionally isolated. (Figure presented.).
