1370003-76-1 Usage
Uses
Different sources of media describe the Uses of 1370003-76-1 differently. You can refer to the following data:
1. YK-11 is a synthetic steroidal selective androgen receptor modulator (SARM).It is a gene-selective partial agonist of the androgen receptor (AR) and does not induce the physical interaction between the NTD/AF1 and LBD/AF2 (known as the N/C interaction), which is required for full transactivation of the AR.
2. YK-11, is a selective androgen receptor modulator. It regulates myogenic differentiation of C2C12 myoblasts by follistatin expression; SARMs
Mechanism of action
YK-11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when used at a concentration of 0.1 μM.1 It induces expression of the androgen receptor target genes FKBP51 and FGF18 in HEK293 cells when used at a concentration of 10 μM. YK-11 accelerates nuclear translocation of androgen receptors without inducing interaction between the androgen receptor N- and C-termini. In C2C12 cells, YK-11 (500 nM) increases expression of the myogenic regulatory factors MyoD, Myf5, and myogenin, as well as follistatin (Fst), and induces myogenic differentiation.
Check Digit Verification of cas no
The CAS Registry Mumber 1370003-76-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,0,0,0 and 3 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1370003-76:
(9*1)+(8*3)+(7*7)+(6*0)+(5*0)+(4*0)+(3*3)+(2*7)+(1*6)=111
111 % 10 = 1
So 1370003-76-1 is a valid CAS Registry Number.