1370007-91-2

Upstream product

• 22115-41-9 2-(bromomethyl)benzonitrile 
• 56568-99-1 (2-cyanobenzyl)(triphenyl)phosphonium bromide 
• 529-19-1 2-Methylbenzonitrile 
• 1370007-83-2 C₂₀H₂₃NO₂ 
• 1370007-79-6 trans-N-{{2-[2-(4-methylphenyl)ethenyl]phenyl}methyl}amine 
• 1370007-87-6 trans-N-{{2-[2-(4-methylphenyl)ethenyl]phenyl}methyl}glycine 

Downstream Products

• 1370007-99-0 3-(4-methylphenyl)-8H-pyrazolo[5,1-a]isoindole 

Relevant academic research and scientific papers

Photochemical and thermal intramolecular 1,3-dipolar cycloaddition reactions of new o-stilbenemethylene-3-sydnones and their synthesis

New trans-and cis-o-stilbene-methylene-sydnones 3a,b were synthesized by transforming the trans-and cis-o-aminomethylstilbene derivative, obtained by reduction of corresponding o-cyano derivatives, into glycine ester derivatives (43 and 31% yield) followed by hydrolysis (90 and 96% yield), nitrosation and ring closure with acetic acid anhydride (30 and 40% yield). The products were submitted to photochemical and thermal intramolecular [3 + 2] cycloadditions to afford diverse heteropolycyclic compounds. Photochemical reactions afforded cis-3-(4-methylphenyl)-3a,8-dihydro-3H-pyrazolo[5,1-a]isoindole (11, 12.5% yield) and trans-3-(4-methylphenyl)-3a,8-dihydro-3H-pyrazolo[5,1-a]isoindole (12, 5% yield). Thermal reactions afforded 3-(4-methylphenyl)-3,3a,8,8a- tetrahydroindeno[2,1-c]pyrazole (14, 50% yield) and 11-(4-methylphenyl)-9,10- diazatricyclo[7.2.1.02,7]dodeca-2,4,6,10-tetraene (15, 22% yield).