1370009-79-2Relevant academic research and scientific papers
Lewis acid promoted highly diastereoselective petasis borono-mannich reaction: Efficient synthesis of optically active β,γ -unsaturated α-amino acids
Li, Yi,Xu, Ming-Hua
supporting information; experimental part, p. 2062 - 2065 (2012/06/04)
An efficient and straightforward method for the preparation of highly enantiomerically enriched β,γ -unsaturated α-amino acid derivatives by a Lewis acid promoted diastereoselective Petasis reaction of vinylboronic acid, N-tert-butanesulfinamide, and glyoxylic acid has been developed. The synthetic utilities of the approach were demonstrated by the rapid and convenient construction of challenging cyclopenta[c]proline derivatives.
