137002-82-5Relevant academic research and scientific papers
Electrophilic Benzylation of 2-Aminopyridine Ring
Kowalski, Piotr
, p. 875 - 879 (2007/10/02)
In the reaction of 2-aminopyridine and its 3- or 5-methyl derivatives with benzyl chloride used in a molar ratio of 1:2, benzylation of 2-aminopyridine ring has been stated that 2-amino-3- or 5-benzylpyridines c as the major products were obtained.Formation of c type compounds took place in the decomposition of 2-benzylamino-3- or 5-benzylpyridines b obtained in the reaction of the 2-benzylaminopyridines a, excess benzyl chloride was used.Production of the b and c compounds, where the benzyl substituent occupied position 3 or 5 in 2-aminopyridine supported the electrophilic mechanism of the reaction (radical reaction was excluded).In the case of 2-aminopyridine and its 3-methyl derivative bis-(2-amino-5-pyridyl)phenylmethanes d were formed as the by-products.
