1370022-06-2Relevant academic research and scientific papers
A catalytic asymmetric reaction involving enolizable anhydrides
Cornaggia, Claudio,Manoni, Francesco,Torrente, Esther,Tallon, Sean,Connon, Stephen J.
supporting information; experimental part, p. 1850 - 1853 (2012/06/16)
In the presence of a highly efficient novel bifunctional organocatalyst at low loadings under mild conditions, enolizable homophthalic anhydrides can be added to a range of aromatic and aliphatic aldehydes to give dihydroisocoumarins, with excellent yields and diastereo-and enantiocontrol (up to 99% ee).
