1370025-65-2Relevant academic research and scientific papers
Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives
Palumbo Piccionello, Antonio,Musumeci, Rosario,Cocuzza, Clementina,Fortuna, Cosimo Gianluca,Guarcello, Annalisa,Pierro, Paola,Pace, Andrea
, p. 441 - 448 (2012)
In the present study the synthesis of new Linezolid-like molecules has been achieved by substitution of the oxazolidinone central heterocyclic moiety with a 1,2,4-oxadiazole ring. Two series of 1,2,4-oxadiazoles, bearing different side-chains and containing a varying number of fluorine atoms, were synthesized and preliminarily tested for biological activity against some Gram-positive and Gram-negative bacteria using Linezolid and Ceftriaxone as reference drugs.
