1370028-06-0Relevant articles and documents
Determination of the absolute structure of (+)-akaterpin
Hosoi, Hayato,Kawai, Nobuyuki,Hagiwara, Hideki,Suzuki, Takahiro,Nakazaki, Atsuo,Takao, Ken-Ichi,Umezaw, Kazuo,Kobayashi, Susumu
experimental part, p. 137 - 143 (2012/03/26)
We describe the total synthesis and structural determination of (+)-akaterpin (1), an inhibitor of phosphatidylinositol- specific phospholipase C (PI-PLC). The key features of the synthetic strategy include the resolution of β,γ-unsaturated ketone (±)-2a with chiral sulfoximine 6. The absolute stereochemistry was determined by comparison of the specific optical rotation data of (+)-1 and (-)-1 with that of natural akaterpin.
