137005-79-9Relevant academic research and scientific papers
Reversal of Diastereofacial Selectivity in the Addition Reaction of Organometallics to Chiral Imines
Ukaji, Yutaka,Watai, Toshiyuki,Sumi, Takashi,Fujisawa, Tamotsu
, p. 1555 - 1558 (2007/10/02)
It was observed that diastereofacial selectivity in the addition reaction of organometallics to the chiral imines derived from (R)-2-methoxy-1-phenylethylamine was regulated under appropriate conditions; i. e., organolithium and organocerium reagents added from the re-face of the chiral imines selectively, while organocopper reagents attacked from the si-face.The utility of the present method was demonstrated in the enantioselective synthesis of solenopsin A.
