1370189-31-3Relevant academic research and scientific papers
Design and synthesis of orally available MEK inhibitors with potent in vivo antitumor efficacy
Adams, Mark E.,Wallace, Michael B.,Kanouni, Toufike,Scorah, Nicholas,O'Connell, Shawn M.,Miyake, Hiroshi,Shi, Lihong,Halkowycz, Petro,Zhang, Lilly,Dong, Qing
, p. 2411 - 2414 (2012/05/05)
The structure-based design, synthesis, and biological evaluation of two novel series of potent and selective MEK kinase inhibitors are described herein. The elaboration of a lead pyrrole derivative to a bicyclic dihydroindolone core provided compounds wit
