1370229-07-4Relevant academic research and scientific papers
Potent norovirus inhibitors based on the acyclic sulfamide scaffold
Dou, Dengfeng,Tiew, Kok-Chuan,Mandadapu, Sivakoteswara Rao,Gunnam, Mallikarjuna Reddy,Alliston, Kevin R.,Kim, Yunjeong,Chang, Kyeong-Ok,Groutas, William C.
experimental part, p. 2111 - 2118 (2012/05/05)
The development of small molecule therapeutics to combat norovirus infection is of considerable interest from a public health perspective because of the highly contagious nature of noroviruses. A series of amino acid-derived acyclic sulfamide-based norovirus inhibitors has been synthesized and evaluated using a cell-based replicon system. Several compounds were found to display potent anti-norovirus activity, low toxicity, and good aqueous solubility. These compounds are suitable for further optimization of pharmacological and ADMET properties.
