1370248-12-6

Basic information

• Product Name: ethyl (S)-4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylate
• Synonyms: ethyl (S)-4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylate
• CAS NO: 1370248-12-6
• Molecular Weight: 566.654
• Mol File: 1370248-12-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl (S)-4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (S)-4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylate(1370248-12-6)
• EPA Substance Registry System: ethyl (S)-4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylate(1370248-12-6)

Safety Data

• Hazardous Substances Data: 1370248-12-6(Hazardous Substances Data)

Upstream product

• 162118-01-6 (S)-2-amino-3,3-diphenyl-1-propanol 
• 727382-68-5 4-benzyloxy-2-(1-dimethylaminomethylidene)-3-oxo-butyric acid ethyl ester 
• 1246616-92-1 ethyl 5-(benzyloxy)-6-formyl-4-oxo-4H-pyran-3-carboxylate 
• 1246616-94-3 ethyl 5-(benzyloxy)-6-((2-methoxyethyl)carbamoyl)-4-oxo-4H-pyran-3-carboxylate 
• 1246616-93-2 3-(benzyloxy)-5-(ethoxycarbonyl)-4-oxo-4H-pyran-2-carboxylic acid 
• 155836-47-8 tert-butyl N-[(1S)-1-(hydroxymethyl)-2,2-diphenylethyl]carbamate 
• 1370248-11-5 ethyl (S)-5-(benzyloxy)-1-(3-hydroxy-1,1-diphenylpropan-2-yl)-6-((2-methoxyethyl)carbamoyl)-4-oxo-1,4-dihydropyridine-3-carboxylate 

Downstream Products

• 1370248-13-7 (S)-4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylic acid 
• 1370237-33-4 (S)-4-benzhydryl-9-hydroxy-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylic acid 
• 1370248-22-8 C₃₂H₃₂N₂O₅ 
• 1370237-80-1 C₂₅H₂₆N₂O₅ 
• 1370248-38-6 (S)-4-benzhydryl-9-(benzyloxy)-N-methoxy-2-(2-methoxyethyl)-N-methyl-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxamide 
• 1370248-39-7 (S)-7-acetyl-4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione 
• 1370248-40-0 C₃₃H₃₂N₂O₆ 
• 1370248-41-1 (S)-4-benzhydryl-9-(benzyloxy)-7-hydroxy-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione 
• 1370248-42-2 (S)-4-benzhydryl-9-(benzyloxy)-7-methoxy-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione 
• 1370237-92-5 (S)-4-benzhydryl-9-hydroxy-7-methoxy-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione 
• 1370248-43-3 (S)-4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione 
• 1370248-44-4 (S)-4-benzhydryl-9-(benzyloxy)-7-bromo-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione 
• 1370237-93-6 C₂₄H₂₃BrN₂O₄ 

Relevant articles and documents

Synthesis and SAR Study of Carbamoyl Pyridone Bicycle Derivatives as Potent Inhibitors of Influenza Cap-dependent Endonuclease

The medicinal chemistry and structure-activity relationships (SAR) for a novel series of carbamoyl pyridone bicycle (CAB) compounds as influenza Cap-dependent endonuclease (CEN) inhibitors are disclosed. Substituent effects were evaluated at the C (N)-1, N-3, and C-7 positions of the CAB ring system using a docking study. Submicromolar EC50 values were achieved in the cellular assay with C-7-unsubstituted CAB which possessed a benzhydryl group on either the C-1 or the N-1 position. An N-3 substituent was found to be critical for the plasma protein binding effect in vitro, and the CAB-N analogue 2v exhibited reasonable total clearance (CLtot). More importantly, compound 2v displayed significant efficacy in a mouse model infected with influenza viruses.