1370261-93-0

Basic information

• Product Name: ethyl 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(methylthio)pyrimidine-5-carboxylate
• Synonyms: ethyl 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(methylthio)pyrimidine-5-carboxylate
• CAS NO: 1370261-93-0
• Molecular Weight: 356.408
• Mol File: 1370261-93-0.mol

Chemical Properties

• CAS DataBase Reference: ethyl 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(methylthio)pyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(methylthio)pyrimidine-5-carboxylate(1370261-93-0)
• EPA Substance Registry System: ethyl 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(methylthio)pyrimidine-5-carboxylate(1370261-93-0)

Safety Data

• Hazardous Substances Data: 1370261-93-0(Hazardous Substances Data)

Upstream product

• 402-67-5 3-fluoro-1-nitrobenzene 
• 342623-98-7 2-(3-nitrophenyl)-2H-1,2,3-triazole 
• 5909-24-0 4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester 
• 626248-56-4 3-(2H-1,2,3-triazol-2-yl)aniline 
• 626-01-7 3-Iodoaniline 

Downstream Products

• 1439905-77-7 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(5,6,7,8-tetrahydroquinolin-8-ylamino)pyrimidin-5-carboxamide 
• 1439905-78-8 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1S,2S)-2-amino-3,3-difluorocyclohexylamino)pyrimidin-5-carboxamide 
• 1439909-25-7 4-(4-bromo-3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(methylsulfinyl)pyrimidin-5-carboxamide 
• 1439909-26-8 4-(3-bromo-5-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(methylsulfinyl)pyrimidin-5-carboxamide 
• 1236187-86-2 tert-butyl (1S,2R)-2-(4-(4-bromo-3-(2H-1,2,3-triazol-2-yl)phenylamino)-5-carbamoylpyrimidin-2-ylamino)cyclohexylcarbamate 
• 1236187-89-5 tert-butyl (1S,2R)-2-(4-(3-bromo-5-(2H-1,2,3-triazol-2-yl)phenylamino)-5-carbamoylpyrimidin-2-ylamino)cyclohexylcarbamate 
• 1194960-89-8 2-((1R,2S)-2-aminocyclohexylamino)-4-(4-bromo-3-(2H-1,2,3-triazol-2-yl)phenylamino)pyrimidin-5-carboxamide 
• 1194960-91-2 2-((1R,2S)-2-aminocyclohexylamino)-4-(3-bromo-5-(2H-1,2,3-triazol-2-yl)phenylamino)pyrimidin-5-carboxamide 
• 1439909-27-9 4-(4-chloro-3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(methylsulfonyl)pyrimidin-5-carboxamide 
• 1439909-29-1 4-(2,4-dichloro-5-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(methylsulfonyl)pyrimidin-5-carboxamide 
• 1439909-28-0 4-(2-chloro-5-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(methylsulfonyl)pyrimidin-5-carboxamide 
• 1370261-94-1 C₁₄H₁₂N₆O₂S 
• 1194973-45-9 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(methylthio)pyrimidine-5-carboxamide 
• 1439905-60-8 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1S,2R)-2-aminocyclohexylamino)pyrimidin-5-carboxamide 

Relevant articles and documents

CYCLOHEXANEDIAMINE COMPOUNDS AND METHODS FOR THEIR PREPARATION

The present invention provides processes for the preparation of cyclohexanediamine compounds of formula Ia and intermediates thereof. The compounds are useful as Syk kinase inhibitors and in various pharmaceutical compositions, and particularly useful for treating conditions mediated at least in part by Syk kinase activity.

SELECTIVE KINASE INHIBITORS

Provided are pyrimidine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.