1370261-96-3 Usage
Uses
Used in Pharmaceutical Industry:
4-(3-(2H-1,2,3-Triazo-2-yl)phenylamino)-2-((1R,2S)-2-aminocyclohexylamino) pyrimidine-5-carboxamide is used as a therapeutic agent for the treatment of leukemia. Its high selectivity for Syk makes it a promising candidate for targeted cancer therapy, as it can potentially disrupt the signaling pathways that contribute to the development and progression of leukemia.
Application Reason:
The compound's ability to selectively inhibit Syk is the primary reason for its use in leukemia treatment. By targeting this specific protein, the compound can potentially reduce the uncontrolled proliferation of leukemia cells and inhibit the growth of the disease. Additionally, its selectivity may result in fewer side effects compared to non-selective treatments, improving the overall safety and tolerability of the therapy.
Check Digit Verification of cas no
The CAS Registry Mumber 1370261-96-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,0,2,6 and 1 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1370261-96:
(9*1)+(8*3)+(7*7)+(6*0)+(5*2)+(4*6)+(3*1)+(2*9)+(1*6)=143
143 % 10 = 3
So 1370261-96-3 is a valid CAS Registry Number.
1370261-96-3Relevant academic research and scientific papers
SELECTIVE KINASE INHIBITORS
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Paragraph 0316; 0342; .343; 0345; 0361, (2013/06/06)
Provided are pyrimidine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.
