1370285-95-2Relevant academic research and scientific papers
An asymmetric organocatalytic approach to Michael reactions of thiazolones and nitroalkenes: Preparation of compounds with anti-cancer potency
Liu, Xiaodong,Song, Hongjin,Chen, Qiao,Li, Wenyi,Yin, Wen,Kai, Ming,Wang, Rui
, p. 6647 - 6655 (2013/01/15)
We present a highly efficient strategy for obtaining a series of chiral 2,4-disubstituted thiazolone derivatives with excellent diastereo-and enantioselectivities through the creation of carbon-and nitrogen-substituted quaternary carbon stereocenters. With the chiral tertiary amine-thiourea catalyst developed by our group, the reactions could be performed smoothly at 1 mol-% catalyst loadings without any additive. Preliminary biological evaluation demonstrated that these analogues could inhibit cell proliferation in vitro significantly.
