1370356-38-9

Upstream product

• 1821-02-9 2-oxopentanoic acid 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1370356-43-6 (3R,4R)-benzyl 3-ethyl-5-nitro-2-oxo-4-(2-nitrophenyl)pentanoate 
• 1370356-39-0 (3R,4R)-benzyl 3-ethyl-5-nitro-2-oxo-4-phenylpentanoate 
• 1370356-40-3 (3R,4R)-benzyl 3-ethyl-5-nitro-2-oxo-4-(4-methoxyphenyl)pentanoate 
• 1370356-41-4 (3R,4R)-benzyl 3-ethyl-5-nitro-2-oxo-4-(4-nitrophenyl)pentanoate 
• 1370356-42-5 (3R,4R)-benzyl 3-ethyl-5-nitro-2-oxo-4-(2-bromophenyl)pentanoate 
• 1370356-47-0 (3R,4S)-benzyl 3-ethyl-4-(nitromethyl)-2-oxo-6-phenylhexanoate 
• 1370356-53-8 (R)-benzyl 3-((3S,4R)-3-nitrochroman-4-yl)-2-oxopentanoate 
• 1370356-45-8 (3R,4R)-benzyl 3-ethyl-5-nitro-2-oxo-4-(furan-3-yl)pentanoate 
• 1370356-46-9 (3R,4R)-benzyl 3-ethyl-4-(1H-indol-3-yl)-5-nitro-2-oxopentanoate 
• 1370356-56-1 benzyl (4S,5S)-3-ethyl-4-(4-methoxyphenyl)-5-nitro-4,5-dihydrofuran-2-carboxylate 

Relevant academic research and scientific papers

Enantioselective Organocatalyzed Consecutive Synthesis of Alkyl 4,5-Dihydrofuran-2-carboxylates from α-Keto Esters and (Z)-β-Chloro-β-nitrostyrenes

Alkyl 4,5-dihydrofuran-2-carboxylates can be efficiently obtained via an enantioselective organocatalyzed consecutive reaction between α-keto esters and (Z)-(2-chloro-2-nitroethenyl)benzenes. The overall sequence combines a (R,R)-TUC-catalyzed Michael addition with a DABCO-promoted intramolecular O-alkylation leading to the title products as single diastereomers with enantiomeric excesses from 86% up to 97%.

Activation of 1,2-keto esters with Takemoto's catalyst toward michael addition to nitroalkenes

When activated with Takemoto's catalyst, 1,2-keto esters constitute versatile nucleophiles in the Michael addition reaction with nitroalkenes affording synthetically valuable, optically active anti-adducts in very good yields and high enantiomeric excesses. Copyright