1370441-36-3Relevant academic research and scientific papers
Programmable enantioselective one-pot synthesis of molecules with eight stereocenters
Potowski, Marco,Schürmann, Markus,Preut, Hans,Antonchick, Andrey P.,Waldmann, Herbert
scheme or table, p. 428 - 430 (2012/07/14)
We developed an enantioselectively catalyzed tandem synthesis of structurally and stereochemically complex molecules that forms four carbon-carbon bonds and sets eight stereocenters with high regio-, diastereo- and enantioselectivity. It can be programmed to yield different stereoisomers by varying only the order of combination of a common set of reagents and catalysts. We report what is to our knowledge the first synthesis of both enantiomers of a chiral compound using the same chiral catalyst.
