1370453-24-9Relevant articles and documents
Highly potent aminopyridines as Syk kinase inhibitors
Castillo, Marcos,Forns, Pilar,Erra, Montse,Mir, Marta,Lopez, Manel,Maldonado, Monica,Orellana, Adelina,Carreno, Cristina,Ramis, Isabel,Miralpeix, Montserrat,Vidal, Bernat
, p. 5419 - 5423 (2012)
A novel class of potent Syk inhibitors has been developed from rational design. Highly potent aminopyridine derivatives bearing a 4-trifluoromethyl-2- pyridyl motif and represented by compound 13b IC50: 0.6 nM were identified. Substitution by a 2-pyrazinyl motif and SAR expansion in position 4 of the central core provided diverse potent non-cytotoxic Syk inhibitors showing nanomolar activity inhibiting human mast cell line LAD2 degranulation.
PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS
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Page/Page column 68, (2012/04/17)
The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by inhibition of Syk kinase and/or Janus kinases.
Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors
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Paragraph 0186, (2013/03/26)
The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by inhibition of Syk kinase and/or Janus kinases.
