1370471-91-2

Upstream product

• 1370472-23-3 C₁₈H₂₆Cl₂N₂O₂ 
• 71387-23-0 4-(prop-2-yn-1-yl 2-oxo-2H-chromene-3-carboxylate) 
• 1370471-34-3 2-azido-N-butyl-N-(2-tert-butylamino)-1-(4-chlorophenyl)-2-oxoethyl acetamide 
• 531-81-7 2-oxo-2H-chromene-3-carboxylic acid 
• 119072-55-8 tert-butylisonitrile 
• 104-88-1 4-chlorobenzaldehyde 

Relevant academic research and scientific papers

Step-economic and cost effective synthesis of coumarin based blue emitting fluorescent dyes

Cost effective and green protocols for the synthesis of two new series of coumarin based blue light emitting fluorophores named as 'Beta Fluors' and 'Alpha Fluors' are described. The coumarin alkylamide based Beta Fluors are developed using a one-step multi-component process in the presence of phenyl boronic acid as an efficient green catalyst. The Alpha Fluors are structured with coumarin-triazole-carboxamide peptidomimetics and their synthesis involves the 'click with MCR' concept. The new fluorophores gave high Stoke's shift values for the emission wavelengths and their structural features are promising for further fine tuning to obtain preferred emission maxima.

Stereoselective synthesis of bio-hybrid amphiphiles of coumarin derivatives by Ugi-Mannich triazole randomization using copper catalyzed alkyne azide click chemistry

An efficient synthesis of ester-triazole-amide amphiphiles of coumarin derivatives by triazole randomization based on click approach is described. Twenty-five small peptide azides were synthesized using Ugi or alternate Mannich-type multi-component reactions. The new azides were then used for the triazole randomization of alkyne functionalized coumarin ester under CuAAC conditions. Sixty-five new peptide bio-hybrids are obtained in near quantitative yield with high regio and stereoselectivity.