13705-29-8Relevant academic research and scientific papers
Catalytic enantioselective desymmetrization of COT-monoepoxide. Maximum deviation from coplanarity for an SN2′-cuprate alkylation
Del Moro, Federica,Crotti, Paolo,Di Bussolo, Valeria,Macchia, Franco,Pineschi, Mauro
, p. 1971 - 1974 (2007/10/03)
(Matrix presented) The first alkylative and enantioselective ring-opening of COT-monoepoxide (1) without the occurrence of any ring-contraction-isomerization by the use of in situ-formed organocuprates is reported. Because of the particular geometric constraint of compound 1, this work reports the largest deviation from coplanarity between the π-orbital of the double bond and the σ-bond connecting the leaving group ever observed for an SN2′-cuprate alkylation.
