1370599-98-6Relevant academic research and scientific papers
Efficient synthesis of novel coumarin-3-carboxamides (=2-oxo-2h-1- benzopyran-3-carboxamides) containing lipophilic spacers
Balalaie, Saeed,Bigdeli, Mohammad Ali,Sheikhhosseini, Enayatollah,Habibi, Azizollah,Moghadam, Hamed Piri,Naderi, Mehrnoush
, p. 528 - 535 (2012)
The novel coumarin-3-carboxamides (=2-oxo-2H-1-benzopyran-3-carboxamides) 5a-5g containing lipophilic spacers were synthesized through the Ugi-four-component reaction (Scheme 1). The reactions of aromatic aldehydes 1, 4,4'-oxybis[benzenamine] or 4,4'-methylenebis[benzenamine] as diamine 2, coumarin-3-carboxylic acid (=2-oxo-2H-benzopyran-3-carboxylic acid; 3), and alkyl isocyanides 4 lead to the desired substituted coumarin-3-carboxamides 5a-5g at room temperature with high bond-forming efficiency. These novel coumarin derivatives exhibit brilliant fluorescence at 544 nm in CHCl 3. Copyright
