1370612-93-3Relevant academic research and scientific papers
Catalytic asymmetric synthesis of chromenes and tetrahydroquinolines via sequential allylic alkylation and intramolecular Heck coupling
Hornillos, Valentin,Van Zijl, Anthoni W.,Feringa, Ben L.
, p. 3712 - 3714 (2012/06/30)
Highly enantioselective synthesis of chiral chromenes and tetrahydroquinolines is achieved by combining asymmetric copper-catalyzed allylic substitution with Grignard reagents and an efficient intramolecular Heck reaction. Moreover, the exocyclic double bond formed in the cyclisation was subjected to RCM, hydroboration and hydrogenation illuminating the synthetic versatility of these heterocycles. The Royal Society of Chemistry 2012.
