1370643-24-5Relevant academic research and scientific papers
NOVEL RECOVERY AND RECYCLING PROCESS OF RACEMIC 4-(4-DIMETHYLAMINO)-1-(4'-FLUOROPHENYL)-1-(HYDROXYBUTYL)-3-(HYDROXYMETHYL)-BENZONITRILE
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Page/Page column 21; 22, (2017/02/09)
Disclosed herein is a novel recovery and recycling process of racemic 4-(4- dimethylamino)-1-(4'-fluorophenyl)-1-(hydroxybutyl)-3-(hydroxymethyl)- benzonitrile (hereinafter referred as cyanodiol). The racemic cyanodiol is an intermediate useful for preparation of Citalopram, Escitalopram or pharmaceutically acceptable salts thereof.
Process development of citalopram/Escitalopram oxalate: Isolation and synthesis of novel impurities
Pramanik, Chinmoy,Hivarekar, Raghvendra R.,Deshmukh, Sanjay S.,Tripathy, Narendra K.,Kotharkar, Sandeep,Chaudhari, Ashok,Gurjar, Mukund K.
experimental part, p. 824 - 829 (2012/08/27)
During process optimization of Escitalopram oxalate novel impurities, 6 and 7 were observed, which were isolated and characterized, and the proposed structure was confirmed by chemical synthesis. Investigation of the cause of impurities formation improved
