1370700-98-3Relevant academic research and scientific papers
Domino Synthesis of 3-Alkyliden-2,3-Dihydro-4-Quinolones
Raga, Esther,Escolano, Marcos,Torres, Javier,Rabasa-Alca?iz, Fernando,Sánchez-Roselló, María,del Pozo, Carlos
supporting information, p. 1102 - 1107 (2019/01/30)
The synthesis of 3-alkyliden-2,3-dihydro-4-quinolones has been accomplished in a domino fashion through a three-step sequence that comprised an initial aza-Baylis-Hillman reaction, followed by a 1,3-rearrangement and an intramolecular amination. Starting from readily available aryl vinyl ketones and N-tosyl imines, the reaction with PPh3, CsOAc and CuI in CH3CN gave rise, in good overall yields, to final 3-alkyliden-4-quinolone derivatives, valuable scaffolds in medicinal chemistry. The simultaneous addition of two bases, PPh3 and CsOAc, was found to be crucial for the success of the process. While PPh3 promoted the reversible aza-Baylis-Hillman reaction, CsOAc triggered the subsequent 1,3-rearrangement, which shifted the initial equilibrium and allowed to complete the synthetic sequence upon the addition of CuI. (Figure presented.).
Sequential one-pot approach for the synthesis of functionalized phthalans via Heck-reduction-cyclization (HRC) reactions
Krishna, Jonnada,Niharika, Pedireddi,Satyanarayana, Gedu
, p. 26749 - 26761 (2015/03/30)
An efficient and practical method is described for the direct synthesis of 1,3-dihydroisobenzofurans, an important structural motif present in biologically active natural or synthetic compounds. The reaction was performed in an almost one-pot fashion via
Palladium-mediated highly regio- and stereoselective intermolecular β-arylation on allylic alcohols: Synthesis of functionalized allylic alcohols
Krishna,Reddy, A. Gopi Krishna,Ramulu, B. Venkat,Mahendar,Satyanarayana
supporting information; experimental part, p. 375 - 380 (2012/03/11)
An efficient and highly regio- and stereoselctive Pd-catalyzed β-arylation method for the formation of β-aryl allylic alcohols, employing aryl iodides, 1-bromo-2-iodobenzenes, and 2-bromobezaldehydes as coupling partners, is presented. The β-aryl allylic
