1370732-71-0 Usage
Uses
Used in Organic Synthesis:
(3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol serves as a valuable building block in organic synthesis, particularly for the creation of pharmaceuticals and agrochemicals. Its unique structure allows for versatile chemical reactions and modifications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its presence in these syntheses contributes to the development of new drugs and therapeutic agents.
Used in Suzuki-Miyaura Coupling Reactions:
One of the primary applications of (3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol is in Suzuki-Miyaura coupling reactions, which are crucial for the formation of carbon-carbon bonds. This reaction is widely used in the synthesis of complex organic molecules, including those found in pharmaceuticals and agrochemicals, making (3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol an essential tool in these processes.
Used in the Production of Pharmaceuticals:
(3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol is used as a precursor in the production of pharmaceuticals. Its reactivity and structural features make it suitable for the synthesis of a variety of drug molecules, contributing to the development of new treatments and medications.
Used in the Production of Agrochemicals:
Similarly, (3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol is utilized in the production of agrochemicals, which include pesticides, herbicides, and other chemicals used in agriculture. Its role in the synthesis of these compounds helps to improve crop protection and yield.
Check Digit Verification of cas no
The CAS Registry Mumber 1370732-71-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,0,7,3 and 2 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1370732-71:
(9*1)+(8*3)+(7*7)+(6*0)+(5*7)+(4*3)+(3*2)+(2*7)+(1*1)=150
150 % 10 = 0
So 1370732-71-0 is a valid CAS Registry Number.
1370732-71-0Relevant academic research and scientific papers
Peiró Cadahía, Jorge,Bondebjerg, Jon,Hansen, Christian A.,Previtali, Viola,Hansen, Anders E.,Andresen, Thomas L.,Clausen, Mads H.
, p. 3503 - 3515 (2018)
A series of novel hydrogen peroxide sensitive prodrugs of methotrexate (MTX) and aminopterin (AMT) were synthesized and evaluated for therapeutic efficacy in mice with collagen induced arthritis (CIA) as a model of chronic rheumatoid arthritis (RA). The prodrug strategy selected is based on ROS-labile 4-methylphenylboronic acid promoieties linked to the drugs via a carbamate linkage or a direct C-N bond. Activation under pathophysiological concentrations of H2O2 proved to be effective, and prodrug candidates were selected in agreement with relevant in vitro physicochemical and pharmacokinetic assays. Selected candidates showed moderate to good solubility, high chemical and enzymatic stability, and therapeutic efficacy comparable to the parent drugs in the CIA model. Importantly, the prodrugs displayed the expected safer toxicity profile and increased therapeutic window compared to MTX and AMT while maintaining a comparable therapeutic efficacy, which is highly encouraging for future use in RA patients.
PRODRUGS ACTIVATED BY REACTIVE OXYGEN SPECIES FOR USE IN THE TREATMENT OF INFLAMMATORY DISEASES AND CANCER
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Page/Page column 25; 32, (2018/09/25)
Prodrugs activated predominantly or exclusively in inflammatory tissue, more particularly prodrugs of methotrexate and derivatives thereof, which are selectively activated by Reactive Oxygen Species (ROS) in inflammatory tissues associated with cancer and inflammatory diseases, as well as method for preparing said prodrugs.
