137081-41-5

Basic information

• Product Name: 1-Fluoro-cyclopropanecarboxylic acid
• Synonyms: 1-Fluoro-cyclopropanecarboxylic acid;1-Fluorocyclopropanecarboxylic;1-Fluorocyclopropane-1-carboxylicacid;Cyclopropanecarboxylic acid, 1-fluoro-;1-Fluoro-Cyclopropanecarboxylic Acid(WXFC0175)
• CAS NO: 137081-41-5
• Molecular Formula: C₄H₅FO₂
• Molecular Weight: 104.0797032
• EINECS: 200-100-1
• Product Categories: cyclopropane
• Mol File: 137081-41-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 63-67℃
• Boiling Point: 120-125℃ (100 Torr)
• Flash Point: 56.6±22.6℃
• Appearance: /
• Density: 1.36±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 2.61±0.20(Predicted)
• CAS DataBase Reference: 1-Fluoro-cyclopropanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Fluoro-cyclopropanecarboxylic acid(137081-41-5)
• EPA Substance Registry System: 1-Fluoro-cyclopropanecarboxylic acid(137081-41-5)

Safety Data

• Safety Statements: 24/25
• RIDADR: UN3261
• Hazardous Substances Data: 137081-41-5(Hazardous Substances Data)

Usage

Uses

1-Fluorocyclopropane-1-carboxylic acid

Upstream product

• 22059-21-8 aminocyclopropane-1-carboxylic acid 
• 154985-93-0 (1-fluorocyclopropyl)methanol 
• 63141-10-6 1-(1-fluorocyclopropyl)ethanone 

Downstream Products

• 149961-53-5 1-fluorocyclopropane-1-carbonyl chloride 
• 137081-15-3 N-(2-methoxy-5-pyridyl)-1-fluorocyclopropanecarboxamide 
• 1446358-59-3 C₂₁H₁₇F₂N₇O₂ 
• 1446359-11-0 C₂₁H₁₇F₂N₇O₂ 

Relevant articles and documents

Intramolecular hydrogen bonding in (1-fluorocyclopropyl)methanol as studied by microwave spectroscopy and quantum chemical calculations

(1-Fluorocyclopropyl)methanol has been studied by microwave spectroscopy in the 12-61GHz spectral region. The rotational spectra of the ground and of four vibrationally excited states belonging to three different normal modes of one rotamer have been assi

3-substituted acrylic acid compound as well as preparation method and application thereof

The invention provides a 3-substituted acrylic acid compound as well as a preparation method and application thereof and in particular relates to a 3-substituted acrylic acid compound, a stereoisomer,a pro-drug, a hydrate or pharmaceutically acceptable salt or ester thereof, and a pharmaceutical composition thereof as well as a preparation method and application thereof. The compound provided bythe invention can inhibit activity of an estrogen receptor, regulate expression level of the estrogen receptor down or induce degradation of the estrogen receptor and can be used for preventing or treating diseases related to overactivity of the estrogen receptor, especially estrogen receptor positive (ER+) drug-resistant diseases (such as breast cancer producing drug resistance to anti-estrogen therapy).

Process for the preparation of 1-fluoro-cyclopropane-1-carboxylic acid

A new process for the preparation of 1-fluoro-cyclopropane-1-carboxylic acid of the formula STR1 which process comprises a) reacting in a first step, a 1-fluoro-cyclopropyl phenyl ketone of the formula STR2 in which R represents hydrogen, halogen, methyl, methoxy, phenyl or phenoxy, with an peroxy compound in the presence of a diluent, and b) reacting, in a second step, the resulting 1-fluoro-cyclopropane-1-carboxylate of the formula STR3 in which R has the abovementioned meaning, with a base in the presence of a diluent, and then acidifying the mixture. New 1-fluoro-cyclopropane-1-carboxylates of the above-mentioned formula.