137097-81-5Relevant academic research and scientific papers
STRICTLY REGIO-CONTROLLED METHOD FOR α-ALKENYLATION OF CYCLIC KETONES VIA PALLADIUM-CATALYZED CROSS COUPLING
Negishi, Ei-ichi,Owczarczyk, Zbyslaw R.,Swanson, Douglas R.
, p. 4453 - 4456 (2007/10/02)
Cyclic α-iodoenones and α-triflyloxyenones, but not α-bromoenones, smoothly react with alkenylzinc and related derivatives in the presence of a catalytic amount of a palladium-phosphine complex, such as Pd(PPh3)4 or Cl2Pd(PPh3)2 treated with n-BuLi (2 equiv), to give α-alkenylenones which can be conjugatively reduced to the corresponding α-alkenyl ketones with complete retention of both enone regiochemistry and alkenyl stereochemistry.
