137105-77-2

Upstream product

• 137105-70-5 (4aR)-5-Methyl-2,4a,6,7-tetrahydropyrido<1,2-b><1,2>oxazin-8(2H)-one 
• 137105-71-6 (4aS,5R)-5-Methyl-2,3,4,4a,6,7-hexahydropyrido<1,2-b><1,2>oxazin-8(2H)-one 
• 137105-69-2 (4R,5E)-N-Hydroxy-4-methyl-5,7-octadienamide 
• 137105-68-1 Methyl (4R,5E)-4-methyl-5,7-octadienoate 
• 142319-54-8 (4R,5E)-4-Methyl-5,7-octadienoic acid 
• 142319-53-7 Methyl (4R)-4-methyl-5-hexenoate 
• 96791-49-0 (4R)-4-methylhex-5-enoic acid 
• 137105-75-0 3-((2S,3R,6S)-1-Benzyl-6-furan-3-yl-3-methyl-piperidin-2-yl)-propan-1-ol 
• 137105-72-7 (4aS,5R)-8-Furan-3-yl-5-methyl-2,3,4,4a,5,6-hexahydro-pyrido[1,2-b][1,2]oxazine 
• 137105-73-8 (4aS,5R,8S)-8-Furan-3-yl-5-methyl-octahydro-pyrido[1,2-b][1,2]oxazine 
• 137105-74-9 3-((2S,3R,6S)-6-Furan-3-yl-3-methyl-piperidin-2-yl)-propan-1-ol 
• 99341-87-4 Methyl (4R)-4-methyl-5-oxopentanoate 
• 917-54-4 methyllithium 
• 137105-76-1 3-((2S,3R,6S)-1-Benzyl-6-furan-3-yl-3-methyl-piperidin-2-yl)-propionic acid methyl ester 

Downstream Products

• 17812-38-3 (-)-nupharamine 

Relevant academic research and scientific papers

Total synthesis of (-)-nupharamine and (+)-3-epinupharamine via asymmetric nitroso Diels-Alder reaction

Chiral synthesis of (-)-nupharamine and (+)-3-epinupharamine, based on elaboration of the intramolecular asymmetric Diels-Alder reaction of N-acylnitroso compounds and the introduction of the furyl group in a fully stereocontrolled manner, is described.