137130-31-5

Upstream product

• 645-66-9 lauric anhydride 
• 6790-21-2 1-(2,4,6-trihydroxyphenyl)-dodecan-1-one 
• 888026-42-4 (2S,4S)-2-(4-benzoxyphenyl)-7-benzoxy-4-(2,4,6-trimethoxy-3-(dodecanoyl)phenyl)chroman 
• 888026-50-4 (2R,4R)-2-(4-benzoxyphenyl)-7-benzoxy-4-(2,4,6-trimethoxy-3-(dodecanoyl)phenyl)chroman 
• 888026-39-9 1-(2,4,6-trimethoxyphenyl)dodecan-1-one 
• 888026-40-2 (2R,3S,4S)-7-(benzoxy)-2-(4-(benzoxy)phenyl)-4-(3-dodecanoyl-2,4,6-trimethoxyphenyl)chroman-3-yl acetate 
• 888026-41-3 (2R,3S,4S)-2-(4-benzoxyphenyl)-7-benzoxy-4-(2,4,6-trimethoxy-3-(dodecanoyl)phenyl)chroman-3-ol 
• 888026-43-5 (2R,3S)-7-(benzoxy)-2-(4-(benzoxy)phenyl)chroman-3-yl acetate 
• 888026-46-8 (2S,3R,4R)-7-(benzoxy)-2-(4-(benzoxy)phenyl)-4-(3-dodecanoyl-2,4,6-trimethoxyphenyl)chroman-3-yl acetate 
• 888026-47-9 (2S,3R,4R)-2-(4-benzoxyphenyl)-7-benzoxy-4-(2,4,6-trimethoxy-3-(dodecanoyl)phenyl)chroman-3-ol 
• 888026-44-6 (2S,3R)-7-(benzoxy)-2-(4-(benzoxy)phenyl)chroman-3-yl acetate 
• 621-23-8 1,2,3-trimethoxybenzene 
• 112-16-3 n-dodecanoyl chloride 
• 888026-38-8 (2R,3S)-2-(4-benzoxyphenyl)-7-benzoxy-4-(2-hydroxyethoxy)chroman-3-yl acetate 

Relevant academic research and scientific papers

Stereoselective synthesis of the atropisomers of myristinin B/C

The first stereoselective synthesis of a potent DNA damaging agent, (-)-myristinin B/C, has been accomplished. This efficient synthesis allowed for unambiguous confirmation of the structure and absolute stereochemistry of the atropisomeric natural product

(+)-Myristinin A, a naturally occurring DNA polymerase β inhibitor and potent DNA-damaging agent

The first stereoselective total synthesis of the naturally occurring flavan myristinin A has been accomplished, as well as its biochemical evaluation. This synthesis verified the structural assignment and allowed for the determination of the absolute ster