137131-35-2

Basic information

• Product Name: 5-methoxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid methyl ester
• Synonyms: 5-methoxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid methyl ester
• CAS NO: 137131-35-2
• Molecular Weight: 157.169
• Mol File: 137131-35-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-methoxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methoxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid methyl ester(137131-35-2)
• EPA Substance Registry System: 5-methoxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid methyl ester(137131-35-2)

Safety Data

• Hazardous Substances Data: 137131-35-2(Hazardous Substances Data)

Upstream product

• 77-78-1 dimethyl sulfate 
• 4931-66-2 methyl 5-oxopyrrolidine-2-carboxylate 
• 149-87-1 Pyroglutamic acid 

Downstream Products

• 107908-43-0 p-nitrobenzyl (5-methoxycarbonyl-2-pyrrolidinylidene)acetate 
• 107938-26-1 benzyl (5-methoxycarbonyl-2-pyrrolidinylidene)acetate 
• 84012-00-0 3-carbomethoxcarbapenam 
• 195311-23-0 methyl (2R*,5R*)-5-methylpyrrolidine-2-carboxylate 
• 160205-11-8 3-Methyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazole-5-carboxylic acid methyl ester 
• 160205-15-2 3-methyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazole-5-carboxylic acid 
• 116340-27-3 1-methoxycarbonyl-6-phenylpyrrolidino<1,2-C>-1,2,4-triazole 
• 258339-27-4 6-acetamido-3-benzylaminocarbonyl-8-methoxycarbonyl-5-oxo-1,2,3,5,6,7-hexahydroindolizine 
• 676148-40-6 4-oxo-3,8-diazabicyclo[3.2.1]octane-2-carboxylic acid methyl ester 

Relevant articles and documents

Impact of Functional Groups on the Copper-Initiated N-Arylation of 5-Functionalized Pyrrolidin-2-ones and Their Vinylogues

The electronic effects governing the N-arylation of pyrrolidone were investigated. The generalization of our preliminary findings on a copper(I)-catalyzed Csp2-N coupling process was first improved with a wide variety of aryl and heteroaryl halides and methyl pyroglutamate. The optimized protocol was further extended to pyrrolidin-2-ones substituted at the C5-position with an aryl group bearing an electron-donating or electron-withdrawing group as well as to some of their substituted enaminoester vinylogues. The impact of substituents at the N- and C5-position on these coupling processes seemed to be pivotal for determining both the reaction profiles and yields.

SYNTHESIS OF 3,5-TRANS-3-METHOXYCARBONYL-1-CARBAPENAM FROM METHYL (+/-)-PYROGLUTAMATE

Synthesis of 3,5-trans-3-methoxycarbonyl-1-carbapenam in six steps from methyl (+/-)-pyroglutamate is described.