1371607-79-2

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• 2415-85-2 3-oxo-N-(p-tolyl)butanamide 

Relevant academic research and scientific papers

Copper-Catalyzed 1,1-Alkylmonofluoroalkylation of Terminal Alkynes with Diazo Compounds and 2-Fluoro-1,3-dicarbonyl Compounds: Access toward (E)-β-Monofluoroalkyl-β,γ-unsaturated Esters or Ketones

An efficient copper-catalyzed three-component 1,1-alkylmonofluoroalkylation of terminal alkynes, diazo compounds, and 2-fluoro-1,3-dicarbonyl compounds for the synthesis of (E)-β-monofluoroalkyl-β,γ-unsaturated esters or ketones has been developed. The methodology features a broad substrate scope, an inexpensive and easily available catalytic system, and excellent selectivity with good yields. The mechanism of the tandem Cu-catalyzed cross-coupling and nucleophilic addition of allenes has been investigated.

Chemoselective Mono- And Difluorination of 1,3-Dicarbonyl Compounds

By altering the amount of Selectfluor, the highly selective mono- and difluorination of 1,3-dicarbonyl compounds has been achieved, affording a variety of 2-fluoro- and 2,2-difluoro-1,3-dicarbonyl compounds in good to excellent yields. The reaction can be readily performed in aqueous media without any catalyst and base, which features practical and convenient fluorination. Importantly, a gram-scale reaction, transformation of 2-fluoro-1,3-diphenylpropane-1,3-dione to 4-fluoro-1,3,5-triphenyl-1H-pyrazole, and chlorination and bromination of 1,3-dicarbonyl compounds are realized to further exhibit its synthetic utility.

Novel synthesis method for 2-fluoro-1,3-dicarbonyl compound

The invention discloses a novel synthesis method for a 2-fluoro-1,3-dicarbonyl compound. Specifically, the novel synthesis method for the 2-fluoro-1,3-dicarbonyl compound comprises the steps that a 1,3-dicarbonyl compound with the structure (I) and a fluo

The synthesis of α,α-difluoroacetamides via electrophilic fluorination in the mixed-solvent of water and PEG-400

Under mild conditions, a series of α,α-difluoro-β- ketoamides were synthesized with Selectfluor as the F + source in the presence of K2CO3 in the mixed-solvent of water and PEG-400 (VH2O:VPEG-400=3:1), without additional phase-transfer catalyst. By using this approach, most cases examined in this study proceeded in nearly quantitative conversions regardless of the electronic nature of the substituent pattern.

Catalyst-free and highly selective electrophilic mono-fluorination of acetoacetamides: Facile and efficient preparation of 2-fluoroacetoacetamides in PEG-400

Series of α-mono-fluorinated acetoacetamides were synthesized under mild condition with industrialized Selectfluor as the F+ source in PEG-400. The approach avoided the use of base or metal catalyst, and most of cases proceeded in nearly quanti