1371607-87-2Relevant academic research and scientific papers
The synthesis of α,α-difluoroacetamides via electrophilic fluorination in the mixed-solvent of water and PEG-400
Zhang, Zhiguo,Bi, Jingjing,Liu, Qingfeng,Zhang, Guisheng
supporting information, p. 45 - 49 (2013/07/05)
Under mild conditions, a series of α,α-difluoro-β- ketoamides were synthesized with Selectfluor as the F + source in the presence of K2CO3 in the mixed-solvent of water and PEG-400 (VH2O:VPEG-400=3:1), without additional phase-transfer catalyst. By using this approach, most cases examined in this study proceeded in nearly quantitative conversions regardless of the electronic nature of the substituent pattern.
Catalyst-free and highly selective electrophilic mono-fluorination of acetoacetamides: Facile and efficient preparation of 2-fluoroacetoacetamides in PEG-400
Bi, Jingjing,Zhang, Zhiguo,Liu, Qingfeng,Zhang, Guisheng
supporting information; experimental part, p. 1159 - 1162 (2012/06/18)
Series of α-mono-fluorinated acetoacetamides were synthesized under mild condition with industrialized Selectfluor as the F+ source in PEG-400. The approach avoided the use of base or metal catalyst, and most of cases proceeded in nearly quanti
