1371636-96-2Relevant academic research and scientific papers
Gold-catalyzed efficient synthesis of 2,4-disubstituted furans from aryloxy-enynes
Li, Ende,Yao, Wenjun,Xie, Xin,Wang, Chengyu,Shao, Yushang,Li, Yanzhong
supporting information; experimental part, p. 2960 - 2965 (2012/05/07)
A series of (E)-1-aryloxy-1-en-3-ynes has been prepared by Sonogashira coupling of 2-bromo-3-aryloxypropenoates with terminal alkynes using Pd(PPh 3)4 and CuI as the catalysts in Et3N. The resulting enynyl-aryl ethers are found to be highly applicable to the synthesis of 2,4-disubstituted furans with an ester group at C-4 position through an Au/Ag-catalyzed annulation reaction under extremely mild reaction conditions. The Royal Society of Chemistry 2012.
