13717-84-5Relevant academic research and scientific papers
Convenient preparation of 3,6-dialkyl-1,6-dihydro-s-tetrazines
Sun, Yaquan,Hu, Weixiao,Yuan, Qing
, p. 2769 - 2775 (2003)
1,6-Dihydro-s-tetrazines such as 1, with a large variety of substituents in the 3- and 6-position of the heterocycle, have been synthesized, and due to their homoaromaticities and their potential reactivities, have aroused more and more interests (Sauer, J. 1,2,4,5-Tetrazines. In Comprehensive Heterocyclic Chemistry II; Boultou, A.J., Ed.; Elsevier: Oxford, UK, 1996; Vol. 6, 901; Neunhoeffer, H. In Comprehensive Heterocyclic Chemistry I; Katritzky, A., Ed.; Pergamon Press Ltd.: Federal Republic of Germany, 1984; Vol. 3, 545).
Synthesis and antitumor activity of s-tetrazine derivatives
Hu, Wei-Xiao,Rao, Guo-Wu,Sun, Ya-Quan
, p. 1177 - 1181 (2007/10/03)
Fifty-five compounds of s-tetrazine derivative including hexahydro-, 1,6-dihydro, 1,4-dihydro-, 1,2-dihydro- and aromatic s-tetrazine were prepared. Their antitumor activities were evaluated in vitro by MTT method for P-388 cell and SRB method for A-549 cell. The results show that there are 9 compounds which in 10-6 μM have more than 50% inhibition rate to A-549 cancer cell growth, and 7 compounds in 10-6 μM have more than 50% inhibition rate to P-388 cancer cell growth. The IC50 of compound 3q for P-388, Bel-7402, MCF-7 and A-549 are 0.6 μM, 0.6 μM, 0.5 μM and 0. 7 μM, respectively. So s-tetrazine derivative is a kind of compound which possesses potential antitumor activities and is worth to research further.
